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1. The mineralocorticoid 9 alpha-fluorohydrocortisone was given to 12 patients with cirrhosis without ascites. In seven an 'escape' from its sodium-retaining effects was observed, the other five continuing to retain sodium. 2. Changes in plasma renin activity (PRA) and inulin clearance (Cinulin) were used in the assessment of possible changes in the 'effective' extracellular fluid volume. PRA fell and Cinulin increased to a similar extent in each of the two groups of patients. The findings do not support the concept that the failure to show the mineralocorticoid escape in some patients with cirrhosis is due to a failure of expansion of the effective extracellular fluid volume. 3. Sodium reabsorption in the different segments of the nephron as estimated by clearance techniques under conditions of maximal water diuresis showed that the greatest changes to account for both mineralocorticoid escape and sodium retention were in the part of the nephron beyond the diluting segment.
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
June 1992,
Gastroenterology,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
June 1992,
Gastroenterology,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
November 1986,
The American journal of physiology,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
September 1985,
The American journal of physiology,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
January 1986,
Clinical science (London, England : 1979),
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
March 1987,
The American journal of physiology,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
March 1982,
Acta endocrinologica,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
November 1978,
The Journal of clinical endocrinology and metabolism,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
March 1987,
The Journal of clinical endocrinology and metabolism,
S P Wilkinson, and
I K Smith, and
H Moodie, and
L Poston, and
R Williams
May 1985,
Federation proceedings,
