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Chromatographic separation of labeled globin chains was performed in stroma-free hemolysates prepared from peripheral blood and bone marrow cells of 11 patients with beta O-thalassemia and 2 patients with sickle cell anemia. A small radioactivity peak, slightly preceding the beta-chain and more prominent in bone marrow cells, was often observed. This peak, which represents synthesis of non-globin proteins, did not exceed 5% of the radioactivity incorporated in the alpha-chain. It is concluded that contamination of the beta-chain with non-globin proteins undoubtedly occurs, but its extent is insufficient to explain the different synthetic ratios which have been repeatedly observed in peripheral blood and in bone marrow cells of patients with heterozygous beta-thalassemia.
G Cividalli, and
H Kerem, and
E A Rachmilewitz
August 1979,
Journal of medical genetics,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
June 1986,
Journal of medical genetics,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
March 1970,
Science (New York, N.Y.),
G Cividalli, and
H Kerem, and
E A Rachmilewitz
March 1970,
Science (New York, N.Y.),
G Cividalli, and
H Kerem, and
E A Rachmilewitz
January 1979,
The Turkish journal of pediatrics,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
January 1987,
Birth defects original article series,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
October 1988,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
July 1972,
Blood,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
February 1978,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
G Cividalli, and
H Kerem, and
E A Rachmilewitz
October 1975,
Proceedings of the National Academy of Sciences of the United States of America,
