Biomaterial Database

[Experimental heterograft tracheal transplants in animals. II (author's transl)]. 1979

O Staindl, and A Lametschwandtner

In sequence with an earlier publication on the results of heterograft tracheal transplants in animals, changes in the Formol-Cialit preserved heterogenous tracheal grafts were studied by light microscopy, and by scanning and transmission electron microscopy. Two main queries arise. Where does the graft respiratory epithelium come from, and what happens to the grafted tracheal cartilage? We found that in the epithelium of graft the number of ciliated cells decreased and that there was ultrastructure evidence of cilial destruction, the goblet cells increased in number, there was a loss of strict polarity of the respiratory epithelium, subepithelial accumulations of cells of probable epithelial origin appeared, and there was a subepithelial accumulation of lymphocytes just beneath the basal lamina. Resorption and transformation of the grafted tracheal cartilage into connective tissue was also observed. Hence, the following conclusions may be made. (1) Small tracheal defects can be corrected by Formol-Cialit preserved heterologous grafts. (2) The mucosa of the host trachea produces a functioning respiratory epithelium in the graft. (3) Tracheal grafts should not exceed 2 x 3 cm in size otherwise a new stenosis from resorption and transformation of grafted cartilage into connective tissue will occur.

UI	MeSH Term	Description	Entries
D002356	Cartilage	A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.	Cartilages
D002923	Cilia	Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)	Motile Cilia,Motile Cilium,Nodal Cilia,Nodal Cilium,Primary Cilia,Primary Cilium,Cilium,Cilia, Motile,Cilia, Nodal,Cilia, Primary,Cilium, Motile,Cilium, Nodal,Cilium, Primary
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014132	Trachea	The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.	Tracheas
D014184	Transplantation, Homologous	Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.	Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic