BIOMAT Database Logo BIOMAT Database Logo

Structure of the major gangliosides from bovine thyroid. 1979

G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers

After preparative isolation, the carbohydrate, long chain base, and fatty acid composition of the major gangliosides from bovine thyroid have been analyzed. The structures were elucidated by determining the molar ratio of the building blocks, permethylation analysis, and enzymatic degradation studies. The following structures are identified: N-Acetylneuraminyl(2,3)-galactosyl(1,4)glucosyl(1,1)ceramidie; N-glycolyneuraminyl(2,3)galactosyl(1,4)glucosyl(1,1)ceramide; galactosyl(1,3)N-acetylgalactosaminyl[(3,2)N-acetylneuraminyl](1,4)galactosyl(1,4)glucosyl(1,1)ceramide; fucosyl(1,2)galactosyl(1,3)N-acetylgalactosaminyl[(3,2)N-acetylneuraminyl](1,4)galactosyl(1,4)glucosyl(1,1)-ceramide. The structures were confirmed by direct inlet mass spectrometry of the permethylated gangliosides and the corresponding asialo derivatives. Structures are proposed for common ions in the different mass spectra.

UI MeSH Term Description Entries
D002240 Carbohydrate Sequence The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS. Carbohydrate Sequences,Sequence, Carbohydrate,Sequences, Carbohydrate
D002241 Carbohydrates A class of organic compounds composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n. The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrate
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002855 Chromatography, Thin Layer Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Chromatography, Thin-Layer,Thin Layer Chromatography,Chromatographies, Thin Layer,Chromatographies, Thin-Layer,Thin Layer Chromatographies,Thin-Layer Chromatographies,Thin-Layer Chromatography
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D005732 Gangliosides A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997) Ganglioside,Sialoglycosphingolipids
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013058 Mass Spectrometry An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers. Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass
D013961 Thyroid Gland A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively. Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids

Related Publications

G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Biosynthesis of bovine thyroid gangliosides.
August 1978, The Journal of biological chemistry,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
The major gangliosides of the bovine pineal body.
January 1987, Lipids,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Neutral glycosphingolipids and gangliosides of bovine thyroid.
June 1982, Journal of biochemistry,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Bovine thyroid gangliosides: distribution pattern after differential pelleting.
October 1974, Archives internationales de physiologie et de biochimie,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Characterization of gangliosides from bovine erythrocyte membranes.
June 1978, The Journal of biological chemistry,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Structures of gangliosides from bovine adrenal medulla.
April 1975, Biochemistry,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
[Structure of gangliosides of normal and leukemic bovine blood lymphocytes].
June 1980, Biokhimiia (Moscow, Russia),
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Gangliosides of the bovine neurohypophysis.
March 1975, Journal of neurochemistry,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Differences in sphingosine and fatty acid patterns of the major gangliosides of bovine retina.
January 1974, FEBS letters,
G A Van Dessel, and A R Lagrou, and H J Hilderson, and W S Dierick, and W F Lauwers
Subcellular structure of bovine thyroid gland. The localization of the peroxidase activity in bovine thyroid.
September 1978, The Biochemical journal,
Copied contents to your clipboard!