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The sympathomimetic drugs noradrenaline, methoxamine, tyramine and norephedrine caused rhythmic contractions in isolated human vasa deferentia. Provided the drug was not washed out, these contractions lasted for the entire duration of the experiment (4-6 h). These contractions were mediated via alpha-adrenoreceptors. Intravenous administration of methoxamine or oxymetazolene to rats or guinea-pigs produced contractions of the vas deferens in vivo in some experiments but was accompanied by severe cardiovascular side effects. A local method of application was developed, using mixtures of tyramine with Silastic prepared as collars specially designed to fit round the vas deferens. Acute and chronic insertion of these slow-releasing devices around the vas deferens of rats produced rhythmic contractions of the vas deferens without any serious side effects.
W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
October 1996,
Methods and findings in experimental and clinical pharmacology,
W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
March 1980,
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W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
April 1977,
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W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
October 1989,
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W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
May 1947,
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W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
February 1984,
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W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
December 1972,
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W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
January 1962,
Lo sperimentale,
W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
November 1978,
Investigative urology,
W D Ratnasooriya, and
R M Wadsworth, and
D P Gilmore
January 1977,
Acta pharmacologica et toxicologica,
