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The prevalence of contact allergic dermatitis and nonallergic irritant reactions to neomycin sulfate was determined in a large group of young adults who had a noteworthy exposure to topical antibiotics. Only two subjects (0.09%) had contact allergy proved by closed patch testing, while 20 (0.9%) had nonallergic irritant reactions to 20% neomycin sulfate and 17 (0.78%) had nonallergic reactions to one of the hydrophilic ointment bases. In a separate population of 653 children referred for diagnostic patch testing, only one subject had contact allergy to neomycin. All three subjects who had reactions had a history of repeated use of neomycin on chronically damaged skin. These results support the conclusion that intermittent use of neomycin on minor cuts and wounds is not associated with an excessive rate of sensitization.
J J Leyden, and
A M Kligman
December 1958,
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J J Leyden, and
A M Kligman
January 1965,
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J J Leyden, and
A M Kligman
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J J Leyden, and
A M Kligman
January 1977,
Nihon rinsho. Japanese journal of clinical medicine,
J J Leyden, and
A M Kligman
January 1965,
Lancet (London, England),
J J Leyden, and
A M Kligman
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Contact dermatitis,
J J Leyden, and
A M Kligman
January 1972,
Nihon Ika Daigaku zasshi,
J J Leyden, and
A M Kligman
December 2014,
World journal of clinical cases,
J J Leyden, and
A M Kligman
January 1966,
JAMA,
J J Leyden, and
A M Kligman
August 2020,
Proceedings (Baylor University. Medical Center),
