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Sera were collected from 108 patients with inflammatory bowel disease and assayed for carcinoembryonic antigen (CEA) and alpha(1)-fetoprotein (AFP). Seven (14%) of 51 patients with ulcerative colitis had a positive test for CEA and one of these had associated carcinoma of the colon. Ten (19%) of 52 patients with regional enteritis were also seropositive. The sera of 4 (9%) of 47 patients with ulcerative colitis and 2 (5%) of 41 patients with regional enteritis contained small amounts of AFP. Of two unclassified patients one had a positive CEA and the other a positive AFP. No serum was positive for both CEA and AFP. In addition, multiple samples were available for sequential analysis in eight CEA-positive patients but there was no apparent relationship between seropositivity and disease activity. Continued follow-up is now in progress to determine the significance of detectable fetal antigen levels in inflammatory bowel disease.
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
May 1969,
The Journal of the Kentucky Medical Association,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
October 1976,
International surgery,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
July 1970,
Schweizerische medizinische Wochenschrift,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
July 1966,
The American journal of digestive diseases,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
September 1951,
The New England journal of medicine,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
July 1973,
Gastroenterology,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
April 1957,
Gastroenterology,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
February 1983,
Meditsinskaia radiologiia,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
January 1983,
Japanese journal of ophthalmology,
W G Thompson, and
R R Gillies, and
H K Silver, and
J Shuster, and
S O Freedman, and
P Gold
May 1987,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
