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Conditions for genetic recombination and laboratory testing of influenza A virus for rapid production of safe vaccine strains needed in human vaccination were developed. The best donors of attenuation were found to include limitingly attenuated outdated vaccine strains adapted to low temperature and having important differentiating features such as thermosensitivity and reduced optimal temperature of neuraminidase activity. Trials in volunteers of a large collection of recombinants produced by recombination of these donors with various virulent strains circulating in 1972--1976 (A/Victoria/72, A/Port Chalmers/73, and A/Virtoria/75) demonstrated complete safety for man of clones with different combinations of rct/40 and OTNA genetic markers.
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
September 1979,
The Journal of general virology,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
August 1972,
The Journal of infectious diseases,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
December 1979,
Journal of virology,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
November 1978,
Virology,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
May 1979,
Virology,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
November 1971,
Acta virologica,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
January 1979,
Intervirology,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
June 1978,
Infection and immunity,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
December 1975,
The Kitasato archives of experimental medicine,
G I Aleksandrova, and
L M Garmashova, and
D B Golubev, and
L I Koliak, and
T E Medvedeva
January 1981,
Virologie,
