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The effect of aspiration of blood on pulmonary host defenses was studied in the rat. Sham and experimental rats had 0.2 ml of saline or blood/100 g body weight injected into their tracheas. One or 24 hours after aspiration rats were challenged with aerosolized, radiolabeled ((32)P), S. aureus. Fourteen hours after bacterial challenge, lungs were removed and intrapulmonary bacterial inactivation was quantified. Significant impairment of bacterial inactivation occurred at both 15 and 38 hours after aspiration of blood, but not after saline. The pulmonary consolidation after aspiration of blood was focal in nature. The lung weight increased but fractional water content decreased. Arterial pH, pCO(2), or pO(2) were unaffected by aspiration of blood. The number and viability of macrophages recovered by lavage were similar in control, sham and experimental groups. If similar impairment in pulmonary host defenses occurred in man following aspiration of blood, the patient with aspiration of blood would have an increased susceptibility to bacterial infection.
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