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Thirty-four healthy blood donors, found to be persistent HBAg carriers, have been investigated by means of serial liver function tests, bromsulphthalein (BSP) retention, and liver biopsy. Thirty-one of the donors had histological abnormalities including one with cirrhosis, three with chronic aggressive hepatitis, and 11 with chronic persistent hepatitis. In 13 biopsies there were focal areas of necrosis in the liver parenchyma. Serial liver function tests revealed abnormalities in each of the donors with cirrhosis or with chronic aggressive hepatitis, in seven of the 11 donors with chronic persistent hepatitis, and in seven of the 13 with focal parenchymal necrosis. The degree of BSP retention was greatest (>11%) in the donors with chronic aggressive hepatitis. The severity of the histological changes was related neither to the titre of the antigen in the serum nor to the presence of autoantibodies.
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
April 1986,
Annals of the Academy of Medicine, Singapore,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
May 1974,
Gastroenterology,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
April 1988,
The Journal of infectious diseases,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
June 1974,
Acta hepato-gastroenterologica,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
September 1993,
Annals of internal medicine,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
December 1986,
Journal of medical virology,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
February 1977,
Revista espanola de las enfermedades del aparato digestivo,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
November 1976,
Gaceta medica de Mexico,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
January 1995,
Nephron,
I L Woolf, and
B E Boyes, and
D M Jones, and
J S Whittaker, and
E Tapp, and
R N MacSween, and
P H Renton, and
F Stratton, and
I W Dymock
February 1988,
Singapore medical journal,
