Biomaterial Database

Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy. 1979

F E Husserl, and R K Lange, and C M Kantrow

Renal papillary necrosis occurred after fenoprofen calcium administration in a patient with systemic lupus erythematosus and urinary tract infection. Possible mechanisms of renal damage may be hypersensitivity, decreased blood flow, and decreased production of a prostaglandin E-like substance.

UI	MeSH Term	Description	Entries
D007681	Kidney Papillary Necrosis	A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.	Renal Papillitis, Necrotizing,Renal Medullary Necrosis,Necrosis, Kidney Papillary,Necrosis, Renal Medullary,Necrotizing Renal Papillitides,Necrotizing Renal Papillitis,Papillary Necrosis, Kidney,Papillitides, Necrotizing Renal,Renal Papillitides, Necrotizing
D008180	Lupus Erythematosus, Systemic	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010666	Phenylpropionates	Derivatives of 3-phenylpropionic acid, including its salts and esters.
D011704	Pyelonephritis	Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.	Necrotizing Pyelonephritis,Pyelonephritis, Acute Necrotizing,Pyelonephritides
D005260	Female		Females
D005279	Fenoprofen	A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.	Fenoprofen Calcium,Fenoprofen Dihydrate, Calcium Salt,Fenoprofen, Anhydrous, Calcium Salt,Nalfon,Nalgesic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014552	Urinary Tract Infections	Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	Infection, Urinary Tract,Infections, Urinary Tract,Tract Infection, Urinary,Tract Infections, Urinary,Urinary Tract Infection