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1. 59Fe-labelled ferric chloride was introduced into tied loops of guinea-pig jejunum. 2. After 5--30 min the loop was removed, the enterocytes were isolated, homogenized and subjected to analytical subcellular fractionation. 3. Uptake of 59Fe was extremely rapid and after 5 min 45% of the radioactivity sedimented in the mitochondrial fraction. 4. Density gradient centrifugation indicated that approximately 80% of this radioactivity was associated with the mitochondria themselves; the remainder was in brush-border fragments. 5. Selective disruption of the mitochondria demonstrates that the iron is localized to the matrix and the inner membrane, indicating transport of the absorbed iron into the organelle. 6. It is suggested that mitochondria are actively implicated at an early stage in the intestinal transport of iron.
J M Hopkins, and
T J Peters
April 1976,
British journal of pharmacology,
J M Hopkins, and
T J Peters
June 1992,
Biochimica et biophysica acta,
J M Hopkins, and
T J Peters
October 1969,
Clinical science,
J M Hopkins, and
T J Peters
August 1990,
Biochemical Society transactions,
J M Hopkins, and
T J Peters
May 1969,
The Journal of physiology,
J M Hopkins, and
T J Peters
July 1974,
Biochemical pharmacology,
J M Hopkins, and
T J Peters
January 1992,
Experimental physiology,
J M Hopkins, and
T J Peters
December 1969,
Immunology,
J M Hopkins, and
T J Peters
January 1953,
Archiv fur Hygiene und Bakteriologie,
J M Hopkins, and
T J Peters
August 1981,
Gut,
