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1 The plasma levels of propranolol and 4-hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4-hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/- s.d.) plasma concentration ratio of 4-hydroxypropranolol to propranolol was 0.130 (+/- 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4-hydroxypropranolol and that of propranolol. 5 Propranolol and 4-hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed.
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
January 1985,
Archives of neurology,
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
April 1979,
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L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
January 1979,
Life sciences,
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
July 1982,
British journal of clinical pharmacology,
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
June 1981,
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L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
September 1978,
Clinica chimica acta; international journal of clinical chemistry,
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
November 1975,
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L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
July 1980,
Clinical pharmacology and therapeutics,
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
September 1971,
British journal of pharmacology,
L Wong, and
R L Nation, and
W L Chiou, and
P K Mehta
January 1984,
Journal of clinical pharmacology,
