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Both ristocetin-induced aggregation in the presence of human factor VIII and bovine factor VIII-induced aggregation of washed normal human platelets were inhibited or reversed by the addition of heparin or dextran sulfate. These actions of dextran sulfate were stronger than those of heparin, and dependent on the sulfur content of dextran sulfate. In order to study the mechanism of actions of dextran sulfate and heparin, the affinity chromatographic experiment of factor VIII in human and bovine plasma, respectively, was carried out by using a dextran sulfate- and a heparin-Agarose column. Both human and bovine factor VIII have a strong affinity for dextran sulfate with high sulfur content and a weak affinity for heparin, but no affinity for dextran sulfate with low sulfur content. From these results, it is suggested that dextran sulfate or heparin binds directly the human and bovine factor VIII, which is an essential factor for the maintenance of the weak interplatelet bonds, and either inhibits or reverses the platelet aggregation.
K Suzuki, and
J Nishioka, and
S Hashimoto
January 1979,
Thrombosis research,
K Suzuki, and
J Nishioka, and
S Hashimoto
December 1977,
Thrombosis and haemostasis,
K Suzuki, and
J Nishioka, and
S Hashimoto
January 1992,
Journal of applied physiology (Bethesda, Md. : 1985),
K Suzuki, and
J Nishioka, and
S Hashimoto
October 1976,
British journal of haematology,
K Suzuki, and
J Nishioka, and
S Hashimoto
November 1973,
Blood,
K Suzuki, and
J Nishioka, and
S Hashimoto
April 1986,
The Journal of surgical research,
K Suzuki, and
J Nishioka, and
S Hashimoto
January 1967,
Federation proceedings,
K Suzuki, and
J Nishioka, and
S Hashimoto
October 1976,
British journal of haematology,
K Suzuki, and
J Nishioka, and
S Hashimoto
July 1981,
British journal of pharmacology,
K Suzuki, and
J Nishioka, and
S Hashimoto
April 2004,
Acta pharmacologica Sinica,
