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3H-thymidine uptake into DNA fractions of rat brain regions was measured following in vivo administration of (methyl-3H)-thymidine and morphine. Acute morphine administration (10 mg/kg; 30 min prior to 3H-thymidine) increased incorporation of 3H-thymidine into DNA of rat striatum. This effect was antagonized by naloxone (1 mg/kg). Further, the observed change in incorporation of 3H-thymidine into DNA in striatum could not be accounted for by differences in the local availability of the label in morphinized rats. An autoradiographic study revealed that the 3H-thymidine was localized in nuclei in cells of the sub-ependymal layer lining the lateral ventricles, an area of glial cell proliferation in adult rats. No change in 3H-thymidine incorporation into DNA was observed in any area of the brain in morphine-addicted rats or in rats undergoing naloxone-precipitated withdrawal. The results indicate that opiates may induce permanent anatomical changes in the brain, including alterations of neuroglial interactions.
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
November 1975,
Pediatric research,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
March 1978,
Biochemical pharmacology,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
January 1986,
Eksperimental'naia onkologiia,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
November 1971,
The Journal of cell biology,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
January 1964,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
January 1978,
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
January 1979,
Progress in neuro-psychopharmacology,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
January 1976,
Biochemical Society transactions,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
January 1981,
Developmental neuroscience,
R B Messing, and
C Dodge, and
J C Waymire, and
G S Lynch, and
S A Deadwyler
December 1990,
Behavioural brain research,
