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When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state of febrile tolerance when repeatedly administered. The second pyrogen, demonstrable during fever in donor rabbits, appears to be similar to endogenous pyrogen described in other experimental fevers. It is postulated that the formation of antigen-antibody complexes constitutes an important initial phase of the febrile reaction in this type of immune fever.
R K Root, and
S M Wolff
January 1985,
Scandinavian journal of gastroenterology. Supplement,
R K Root, and
S M Wolff
March 1989,
The American journal of physiology,
R K Root, and
S M Wolff
March 1978,
Vestnik khirurgii imeni I. I. Grekova,
R K Root, and
S M Wolff
January 1967,
Advances in immunology,
R K Root, and
S M Wolff
January 1969,
Allergie und Asthma,
R K Root, and
S M Wolff
April 1972,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
R K Root, and
S M Wolff
January 1976,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
R K Root, and
S M Wolff
November 2012,
Hematology (Amsterdam, Netherlands),
R K Root, and
S M Wolff
January 1973,
Bulletin of the World Health Organization,
R K Root, and
S M Wolff
July 1983,
Kidney international,
