BIOMAT Database Logo BIOMAT Database Logo

Effects of the H2 receptor antagonist cimetidine on pituitary hormones in man. 1979

G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser

The effects of the histamine (H2) receptor antagonist cimetidine on serum levels of prolactin (PRL), growth hormone (GH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH) and cortisol were studied in five normal males. Cimetidine, when given by infusion at the dose of 100 mg/h for 5 h, did not alter adenohypophyseal secretion either basally or after pituitary stimulation with LHRH and TRH. However, 400 mg cimetidine given intravenously as a bolus injection significantly stimulated PRL release in all subjects, without affecting any other measured hormone. A dose-reponse relationship existed, and 200 mg cimetidine seems to be the minimum PRL-releasing dose when given as an intravenous bolus injection. These results suggest that cimetidine releases PRL and that this effect is dose-related, but only when large intravenous injections are given.

UI MeSH Term Description Entries
D007263 Infusions, Parenteral The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping. Intra-Abdominal Infusions,Intraperitoneal Infusions,Parenteral Infusions,Peritoneal Infusions,Infusion, Intra-Abdominal,Infusion, Intraperitoneal,Infusion, Parenteral,Infusion, Peritoneal,Infusions, Intra-Abdominal,Infusions, Intraperitoneal,Infusions, Peritoneal,Intra Abdominal Infusions,Intra-Abdominal Infusion,Intraperitoneal Infusion,Parenteral Infusion,Peritoneal Infusion
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008297 Male Males
D010903 Pituitary Gland, Anterior The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION. Adenohypophysis,Anterior Lobe of Pituitary,Anterior Pituitary Gland,Lobus Anterior,Pars Distalis of Pituitary,Adenohypophyses,Anterior Pituitary Glands,Anterior, Lobus,Anteriors, Lobus,Lobus Anteriors,Pituitary Anterior Lobe,Pituitary Glands, Anterior,Pituitary Pars Distalis
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D002927 Cimetidine A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output. Altramet,Biomet,Biomet400,Cimetidine HCl,Cimetidine Hydrochloride,Eureceptor,Histodil,N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine,SK&F-92334,SKF-92334,Tagamet,HCl, Cimetidine,Hydrochloride, Cimetidine,SK&F 92334,SK&F92334,SKF 92334,SKF92334
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005640 Follicle Stimulating Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. FSH (Follicle Stimulating Hormone),Follicle-Stimulating Hormone,Follitropin
D006146 Guanidines A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.

Related Publications

G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
Effects of the H2 receptor antagonist ranitidine on anterior pituitary hormone secretion in man.
January 1982, European journal of clinical pharmacology,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
[Effects of cimetidine, a histamine H2 receptor antagonist, on prolactin release].
September 1983, Horumon to rinsho. Clinical endocrinology,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
[The effects of an H2 receptor antagonist (cimetidine) in asthmatic patients].
January 1985, Arerugi = [Allergy],
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.
December 1975, British journal of clinical pharmacology,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
Physicochemical properties of the H2-receptor antagonist cimetidine.
December 1980, The Journal of pharmacy and pharmacology,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
Effects of cimetidine, H2 receptor antagonist, on follicular and luteal development in the mice.
June 1994, Biomedical and environmental sciences : BES,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
Effect of histamine H2-receptor antagonist (cimetidine) on intra-ocular pressure.
March 1988, Journal of the Indian Medical Association,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
The pharmacology of cimetidine, a new histamine H2-receptor antagonist.
March 1975, British journal of pharmacology,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
The metabolism and elimination of cimetidine, a histamine H2-receptor antagonist, in the rat, dog, and man.
January 1978, Drug metabolism and disposition: the biological fate of chemicals,
G Delitala, and W A Stubbs, and J A Wass, and A Jones, and S Williams, and G M Besser
The influence of cimetidine, a histamine H2-receptor antagonist, on the gastric effects of reserpine in rats.
March 1981, European journal of pharmacology,
Copied contents to your clipboard!