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Four male subjects were given phenytoin orally in single or twice-daily doses. Subjects were on 2 or 3 different dosing rates from 260 to 600 mg phenytoin sodium daily. Predose blood samples were obtained almost daily. The resulting serum levels, measured by gas-liquid chromatography, ranged from 1 to 18 micrograms/ml. Serum phenytoin concentration-time data were fit to a 1-compartment open model with zero-order input and Michaelis-Menten elimination. The resulting computer-generated parameter estimates (Vmax, 5.28 to 8.41 mg/kg/day; Km, 0.83 to 4.18 mg/1; Vd, 0.74 to 0.97 1/kg) are in agreement with the ranges of values in the literature. The time course of phenytoin cumulation is compatible with the presence of a major elimination pathway exhibiting Michaelis-Menten kinetic behavior.
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
December 1983,
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J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
March 1978,
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J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
June 1969,
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J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
May 1980,
Clinical pharmacology and therapeutics,
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
August 1976,
Neurology,
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
July 1977,
Medizinische Klinik,
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
January 1986,
Progress in clinical and biological research,
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
October 1982,
Psychiatrie, Neurologie, und medizinische Psychologie,
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
January 1982,
Neurology,
J P Allen, and
T M Ludden, and
S R Burrow, and
W A Clementi, and
S A Stavchansky
August 1983,
Psychiatrie, Neurologie, und medizinische Psychologie,
