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Studies of metoprolol in asthmatic patients showed beta 1-selective blocking properties on the adrenergic receptor. Metoprolol in a dose of 40 mg given orally to 9 asthmatic patients significantly decreased the pulse rate at 60 and 120 minutes and the systolic blood pressure at 120 minutes but did not cause any increase of respiratory impedance, measured by the forced oscillation technique. A double-blind test was carried out to compare the effects of metoprolol and inactive placebo on the respiratory response to isoproterenol in 24 asthmatic patients. In the metoprolol group, systolic blood pressure decreased significantly and pulse rate at rest also tended to decrease. There was no significant difference between the metoprolol and placebo groups in the respiratory response to an isoproterenol aerosol.
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T Takishima
March 1978,
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
S Mue, and
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T Takishima
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Infection and drug resistance,
S Mue, and
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January 1983,
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T Takishima
January 1961,
Gazeta medica portuguesa,
S Mue, and
T Sasaki, and
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M Takahashi, and
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K Yamauchi, and
S Suzuki, and
W Hida, and
T Takishima
January 1965,
Medicina,
S Mue, and
T Sasaki, and
S Shibahara, and
M Takahashi, and
T Ohmi, and
K Yamauchi, and
S Suzuki, and
W Hida, and
T Takishima
September 2007,
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
S Mue, and
T Sasaki, and
S Shibahara, and
M Takahashi, and
T Ohmi, and
K Yamauchi, and
S Suzuki, and
W Hida, and
T Takishima
December 1981,
European journal of respiratory diseases,
S Mue, and
T Sasaki, and
S Shibahara, and
M Takahashi, and
T Ohmi, and
K Yamauchi, and
S Suzuki, and
W Hida, and
T Takishima
December 2006,
Revista portuguesa de pneumologia,
