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The solid-state conformational analysis of t-AOC-L-Pro-OH has indicated that the molecules are not folded up to form an oxy-C7 peptide conformation, but rather that they are held together through intermolecular O-H .... 0 = C (urethane) hydrogen bonds. The tertiary amide bond is in the cis configuration. In solvents of high polarity strongly solvated species largely predominate. In cyclohexane solution non-associated and associated (involving the carboxyl C = O as the proton acceptor) species are simultaneously present. Obviously, the extent of association increases with increasing solute concentration. The amount of the oxy-C7 form, if any, should be extremely small. It is also demonstrated that CD measurements alone can lead to an incorrect picture of the conformational preferences of amino acid derivatives and small peptides in solution.
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
January 1977,
Macromolecules,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
April 1992,
International journal of peptide and protein research,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
January 2005,
Magnetic resonance in chemistry : MRC,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
April 1971,
Journal of the American Chemical Society,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
March 2010,
Protein and peptide letters,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
September 1988,
International journal of peptide and protein research,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
January 2013,
Acta crystallographica. Section E, Structure reports online,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
February 1975,
Biochemistry,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
May 2001,
Biopolymers,
E Benedetti, and
A Ciajolo, and
B di Blasio, and
V Pavone, and
C Pedone, and
C Toniolo, and
G M Bonora
April 1988,
International journal of peptide and protein research,
