Biomaterial Database

Note on the metabolism of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate. 1979

B Gabard, and R Walser

Chromatographic analysis of the radioactive urine obtained after injection into rats of [1,3-(14)C] dimercaptopropane sodium sulfonate (DMPS, Dimaval) showed that part of the administered chelating agent is excreted unchanged. This was confirmed by the results of studies of sulfur excretion in the different fractions of the urine as well as by titration of the excreted thiol groups. The results show that, at least in rats, DMPS is not involved in important metabolic reactions.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004112	Dimercaprol	An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.	2,3-Dimercaptopropanol,2,3-Dithiopropan-1-o1,B.A.L.,BAL in Oil,British Anti-Lewisite,British Anti-Lewisite Agent,Cadmium 2,3-Dimercaptopropanol,Dicaptol,2,3 Dimercaptopropanol,2,3 Dithiopropan 1 o1,2,3-Dimercaptopropanol, Cadmium,Anti-Lewisite Agent, British,Anti-Lewisite, British,British Anti Lewisite,British Anti Lewisite Agent,Cadmium 2,3 Dimercaptopropanol,Oil, BAL in,in Oil, BAL
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013431	Sulfates	Inorganic salts of sulfuric acid.	Sulfate,Sulfates, Inorganic,Inorganic Sulfates
D013455	Sulfur	An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	Sulfur-16,Sulfur 16
D014494	Unithiol	A chelating agent used as an antidote to heavy metal poisoning.	2,3-Dimercapto-1-propanesulfonic Acid,2,3-Dimercaptopropane 1-Sodium Sulfonate,2,3-Dimercaptopropane-1-sulfonate Sodium,2,3-Dimercaptopropanesulfonic Acid,DMPS,DMPS-Heyl,Dimaval,Mercuval,Sodium 2,3-Dimercaptopropane Sulfonate,Sodium 2,3-Dithiopropanesulfate,Unitiol,1-Sodium Sulfonate, 2,3-Dimercaptopropane,2,3 Dimercapto 1 propanesulfonic Acid,2,3 Dimercaptopropane 1 Sodium Sulfonate,2,3 Dimercaptopropane 1 sulfonate Sodium,2,3 Dimercaptopropanesulfonic Acid,2,3-Dimercaptopropane Sulfonate, Sodium,2,3-Dithiopropanesulfate, Sodium,DMPS Heyl
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus