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This research tested the hypothesis that in hyperactive children a low dose of methylphenidate (0.3 mg/kg) would produce scores superior to those with a high dose (1.0 mg/kg) or placebo on the matching familiar figures test (MFF), a primary index of impulsivity. The hypothesis was based on an earlier finding that the highest percentage of correct responses on a short-term memory task were found in hyperactive subjects who were receiving 0.3 mg/kg of methylphenidate whereas at 1.0 mg/kg the percentage correct returned to the placebo level. The hypothesis was verified in that the low dose reduced the number of errors on the MFF significantly more than did placebo or the high dose. This work demonstrates that, for both learning and impulsivity in hyperactive children, the lower dose of the two doses of methylphenidate studied produced the preferable effect.
R T Brown, and
E K Sleator
December 1977,
Science (New York, N.Y.),
R T Brown, and
E K Sleator
January 1967,
Western medicine; the medical journal of the west,
R T Brown, and
E K Sleator
December 1979,
British journal of clinical pharmacology,
R T Brown, and
E K Sleator
April 1977,
Psychopharmacology bulletin,
R T Brown, and
E K Sleator
January 1974,
Clinical pediatrics,
R T Brown, and
E K Sleator
January 1976,
Journal of abnormal child psychology,
R T Brown, and
E K Sleator
October 1989,
Pediatrics,
R T Brown, and
E K Sleator
June 1985,
Journal of abnormal child psychology,
R T Brown, and
E K Sleator
April 1993,
Journal of child neurology,
R T Brown, and
E K Sleator
October 1974,
Psychopharmacology bulletin,
