Biomaterial Database

[Effect of deficient and excess thiamine on the lipid makeup of the rat liver plasma membranes]. 1979

A N Sevost'ianov

Single administration of thiamin at a high dose (40 mg) 100 g of body weight into rats led to an increase in content of phospholipids in liver plasmatic membranes; cholesterol and the ratio between phospholipid fractions were unaltered. Maintaining of rats on a rice diet (dietary B1-avitaminosis) as well as a single administration of hydroxythiamin into animals at doses 10 mg and 40 mg per 100 g of body weight did not affect the content of cholesterol and phospholipids in liver plasmatic membranes. At the same time, the ratio of the phospholipid fraction was altered in plasmatic membranes: in dietary B1-avitaminosis content of lecithin was decreased and the content of lysolecithin was increased, high of hydroxythiamin decreased the content of sphingomyelin. Hydroxythiamin at a dose of 10 mg/kg of body weight did not affect these patterns.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008563	Membrane Lipids	Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.	Cell Membrane Lipid,Cell Membrane Lipids,Membrane Lipid,Lipid, Cell Membrane,Lipid, Membrane,Lipids, Cell Membrane,Lipids, Membrane,Membrane Lipid, Cell,Membrane Lipids, Cell
D010119	Oxythiamine	Thiamine antagonist, antimetabolite.	Hydroxythiamine
D010743	Phospholipids	Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.	Phosphatides,Phospholipid
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013831	Thiamine	3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.	Aneurin,Vitamin B 1,Thiamin,Thiamine Mononitrate,Vitamin B1,Mononitrate, Thiamine