Biomaterial Database

The disposition of spirohydantoin mustard (NSC 172112) in rats and dogs. 1979

J Plowman, and R H Adamson

1. The disposition of spirohydantoin mustard (SHM) has been examined in rats and dogs after i.v. administration of (hydantoin-4-14C]SHM and [2-chloroethyl-U-14C]SHM. 2. Four hours after dosing to rats and dogs, renal clearance of the ethyl-14C moiety (14--21%) is lower than that of the hydantoin-14C moiety (29--68%). In contrast, biliary excretion of the ethyl-14C in rats is greater, and there appears to be enterohepatic circulation of the ethyl-14C. 3. Less than 1% of the radioactivity appearing in rat bile is unchanged SHM. Two major metabolites containing the ethyl-14C moiety are conjugates of glutathione or cysteine. 4. Levels of 14C in plasma decline in a biphasic manner. No difference in the initial plasma disappearance of the two labelled moieties is observed, but disappearance of the ethyl-14C During the second phase is slower. 5. Concentrations of ethyl14C and hydantoin-14C in the brains of rats and dogs, 4 h after i.v. administration, are equivalent to those in plasma. 6. Radioactivity is also distributed to the brain of rats after oral administration of [2-chloroethyl-J-14C]SHM, but at a concn. less than half that of plasma.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009588	Nitrogen Mustard Compounds	A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.	Compounds, Nitrogen Mustard,Mustard Compounds, Nitrogen
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D006827	Hydantoins	Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.	Hydantoin,Imidazolidine-2,4-Diones,Imidazolidine 2,4 Diones
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001646	Bile	An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.	Biliary Sludge,Sludge, Biliary
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor