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A controlled field trial of oral killed typhoid vaccine was carried out in Delhi, India in 1968-69. Altogether, 13 374 children below the age of 17 years were included in the study. Two comparable groups of children were given either placebo or vaccine. Each tablet of vaccine contained 100x10(9) killed Salmonella typhi, and 3 tablets of vaccine or placebo were administered to each child. The vaccinated subjects were followed up from 10 June 1968 to 31 August 1969. The effectiveness of the vaccine was measured by comparing the incidence of typhoid fever (based only on bacteriologically positive cases) in the two groups. It was found that the difference in incidence of the disease in the two groups was not statistically significant. The oral killed typhoid vaccine in the dosage schedule used in the present trial was found not to be effective against the disease.
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
January 1961,
Zeitschrift fur Hygiene und Infektionskrankheiten; medizinische Mikrobiologie, Immunologie und Virologie,
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
January 1974,
Acta microbiologica Academiae Scientiarum Hungaricae,
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
January 1976,
Developments in biological standardization,
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
January 1976,
Developments in biological standardization,
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
July 1993,
The Journal of the Association of Physicians of India,
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
January 1976,
Journal of hygiene, epidemiology, microbiology, and immunology,
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
December 1991,
Lancet (London, England),
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
March 1983,
Lancet (London, England),
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
March 1967,
Public health reports (Washington, D.C. : 1896),
C S Chuttani, and
K Prakash, and
A Vergese, and
U Sharma, and
P Singha, and
B G Ray
January 1974,
The Indian journal of medical research,
