Biomaterial Database

Comparison of avidin induction in the differentiated and undifferentiated chick oviduct by progesterone, actinomycin D and oviductal injury. 1979

H A Elo

Various oestrogen (diethylstilboestrol, DES) pre-treatments were carried out on chicks and the production of avidin in the oviduct was induced by progesterone, actinomycin D or oviductal injury. Avidin induction was dose-dependent at doses between 5 mg and 40 mg progesterone/kg or 50 micrograns and 300 micrograms actinomycin D/kg respectively. The induction by oviductal injury correlated with the magnitude of tissue injury. First signs of avidin induction were seen at 4 h after oviductal injury, 12 h after progesterone or 12--16h after actinomycin D administration. Actinomycin D (200 micrograms/kg), when administered after progesterone injection, did not increase avidin induction by progesterone, this indicating that avidin induction by actinomycin D is not a "superinduction" effect. Evidence is presented here that the mechanism of avidin induction by oviductal injury and actinomycin D differs from that by progesterone. The differentiation of the oviduct caused by DES treatment was necessary for the induction by progesterone, whereas actinomycin D and oviductal injury also induced avidin in the undifferentiated or poorly differentiated oviduct. Simultaneous DES stimulation potentiated induction by progesterone but not by actinomycin D or oviductal injury. Furthermore, single prior DES stimulation increased avidin induction in the differentiated oviduct of DES-withdrawn chicks caused by progesterone but not that by actinomycin D or oviductal injury.

UI	MeSH Term	Description	Entries
D010047	Ovalbumin	An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	Serpin B14
D010057	Oviducts	Ducts that serve exclusively for the passage of eggs from the ovaries to the exterior of the body. In non-mammals, they are termed oviducts. In mammals, they are highly specialized and known as FALLOPIAN TUBES.	Oviduct
D011374	Progesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.	Pregnenedione,Progesterone, (13 alpha,17 alpha)-(+-)-Isomer,Progesterone, (17 alpha)-Isomer,Progesterone, (9 beta,10 alpha)-Isomer
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D003609	Dactinomycin	A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	Actinomycin,Actinomycin D,Meractinomycin,Cosmegen,Cosmegen Lyovac,Lyovac-Cosmegen,Lyovac Cosmegen,Lyovac, Cosmegen,LyovacCosmegen
D004054	Diethylstilbestrol	A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)	Stilbestrol,Agostilben,Apstil,Diethylstilbestrol, (Z)-Isomer,Diethylstilbestrol, Disodium Salt,Distilbène,Stilbene Estrogen,Tampovagan,Estrogen, Stilbene
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001360	Avidin	A specific protein in egg albumin that interacts with BIOTIN to render it unavailable to mammals, thereby producing biotin deficiency.