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Various well-known agents with a favourable influence on cerebral circulation were used as a basis for creating new methods to asses the effects on this vascular region in experimental animals. A technique was worked out for radiocirculography and simultaneous radiometry, as well as for scanning and simultaneous radiometry of cat brain. Radiocirculography, followed by scintigraphy, proved to be among the best methods used for assessment of the effect of As2 on cerebral circulation. Simultaneous radiometry with the methods mentioned above had only orientational value. Radiocirculographic and scanning data after application of As2 in a dose of 10 mg/kg are close to those for nicotinic acid in a dose of 1 mg/kg. Similar to the data of the isotopic methods after application of As2 in a dose of 5 mg/kg are the results obtained with 5 mg/kg cinnarizin, which suggests a similar machanism of action.
T Katsarov, and
M Nikolova, and
R Nikolov
January 1976,
Arzneimittel-Forschung,
T Katsarov, and
M Nikolova, and
R Nikolov
January 1979,
Acta physiologica et pharmacologica Bulgarica,
T Katsarov, and
M Nikolova, and
R Nikolov
January 1950,
Helvetica physiologica et pharmacologica acta,
T Katsarov, and
M Nikolova, and
R Nikolov
November 1965,
Vascular diseases,
T Katsarov, and
M Nikolova, and
R Nikolov
October 1981,
Vrachebnoe delo,
T Katsarov, and
M Nikolova, and
R Nikolov
April 1967,
Casopis lekaru ceskych,
T Katsarov, and
M Nikolova, and
R Nikolov
November 1965,
Munchener medizinische Wochenschrift (1950),
T Katsarov, and
M Nikolova, and
R Nikolov
January 1974,
Radiologia diagnostica,
T Katsarov, and
M Nikolova, and
R Nikolov
January 1953,
Cardiologia,
T Katsarov, and
M Nikolova, and
R Nikolov
January 1976,
Acta physiologica et pharmacologica Bulgarica,
