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Estimation of urinary kininogenase activity by radioimmunoassay of generated kinin was studied. Bovine serum low molecular weight kininogen was proved not to cross-react with kallidin antibody and also bradykinin antibody. This kininogen was used as substrate measuring urinary kininogenase activity. Separation of released kinin from the kininogen was not required in the present method. Urinary kallikrein activity was found to be significantly decreased in essential hypertension, in chronic glomerulonephritis and in patients who had received renal transplantation. On the contrary, an increase in urinary kallikrein was found in primary aldosteronism and in Bartter's syndrome. The present method was very useful for measuring kininogenase activity.
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
October 1984,
Endocrinologia japonica,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
February 1977,
Biokhimiia (Moscow, Russia),
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
November 1994,
Biochemical and biophysical research communications,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
January 1980,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
March 1971,
Journal of biochemistry,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
January 1983,
Proceedings of the National Academy of Sciences of the United States of America,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
January 1978,
Journal of biochemistry,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
July 1963,
Biochemische Zeitschrift,
K Abe, and
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T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
August 1987,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
K Abe, and
H Kato, and
Y Sakurai, and
T Itoh, and
K Saito, and
T Haruyama, and
Y Otsuka, and
K Yoshinaga
September 1985,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
