-transparent.png){kind=logo}
Cook, Thomas M. (Sterling-Winthrop Research Institute, Rensselaer, N.Y.), Karen G. Brown, James V. Boyle, and William A. Goss. Bactericidal action of nalidixic acid on Bacillus subtilis. J. Bacteriol. 92:1510-1514. 1966.-Nalidixic acid at moderate concentrations exerts a bactericidal action upon the gram-positive bacterium Bacillus subtilis. The synthesis of deoxyribonucleic acid (DNA) in B. subtilis is selectively inhibited by nalidixic acid at concentrations approximating the minimal growth inhibitory concentration. Higher concentrations (25 mug/ml) result in a 30 to 35% degradation of DNA. After extended exposure to nalidixic acid, protein synthesis is also depressed. Cells of B. subtilis treated with nalidixic acid exhibit characteristic morphological abnormalities including cell elongation and development of gram-negative areas. From the results presented, it can be concluded that the mode of action of nalidixic acid upon susceptible bacteria is similar for both gram-positive and gram-negative species.
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
August 1973,
Journal of virology,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
January 1997,
Current microbiology,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
April 1969,
Journal of bacteriology,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
November 1969,
Journal of bacteriology,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
July 1994,
Molecular & general genetics : MGG,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
January 1982,
Zeitschrift fur allgemeine Mikrobiologie,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
February 1983,
Journal of general microbiology,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
September 1953,
Applied microbiology,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
September 1974,
Biochimica et biophysica acta,
T M Cook, and
K G Brown, and
J V Boyle, and
W A Goss
April 1970,
Journal of general microbiology,
