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By stimulating or depressing the macrophage system with Corynebacterium parvum or anti-macrophage serum, we were able to establish that macrophages play a role in Poly-I:C-induced interferon production. On the other hand macrophages do not seem to be the cells which produce endotoxin- or NDV-induced interferon, although a slight participation of these cells in the production of NDV-induced interferon cannot be excluded.
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