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The thermal inactivation kinetics of glucose-6-phosphate dehydrogenase during ageing of human diploid cells were studied. It was shown that semi-logarithmic anamorphisms of the thermal inactivation kinetic curves may be presented as a total of two rectilinear sites corresponding to the thermolabile and thermostable fractions of the enzyme. In ageing cells the enzyme stability is decreased as compared to the young ones due to the increase in the amount of the thermolabile fraction. It was also found that despite a certain variability in the process of the cell growth at the 22nd passage the thermal stability of glucose-6-phosphate dehydrogenase is decreased, while the enzyme thermal stability in the cells at the 52nd passage is monotonously increased. Purification of the enzyme from ageing and young human diploid cells results in an increase of the enzyme stability. However, when the enzyme was isolated from young cells, it possessed a higher thermal stability.
S B Alekseev, and
V B Mamaev, and
L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
February 1974,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
S B Alekseev, and
V B Mamaev, and
L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
January 1983,
Development, growth & differentiation,
S B Alekseev, and
V B Mamaev, and
L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
June 1979,
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S B Alekseev, and
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L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
January 1975,
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S B Alekseev, and
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L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
May 1965,
Biochimica et biophysica acta,
S B Alekseev, and
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L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
August 2012,
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S B Alekseev, and
V B Mamaev, and
L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
January 1968,
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S B Alekseev, and
V B Mamaev, and
L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
July 1974,
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S B Alekseev, and
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L I Kalinina, and
O G Andzhaparidze
December 1997,
Comparative biochemistry and physiology. Part A, Physiology,
S B Alekseev, and
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L G Stepanova, and
L I Kalinina, and
O G Andzhaparidze
January 1971,
Bulletin of the World Health Organization,
