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The cytokinetic response of a human colon carcinoma cell line to cis-dichlorodiammineplatinum(II) was investigated using flow cytometry of DNA content, autoradiography after pulse and continuous tritiated thymidine exposure, and mitotic accumulation after continuous Colcemid treatment. With increasing concentration and exposure time, cis-dichlorodiammineplatinum(II) delayed and then blocked cycle traverse in S and G2 phases. After prolonged treatment with high concentrations of cis-dichlorodiammineplatinum(II), an additional block in G1 or at the G1-S boundary was established. Irreversibility of cell cycle distribution changes after prolonged observation periods suggests cell death in G2, S, and G1 compartments.
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Cancer treatment reports,
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J P Bergerat, and
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J P Bergerat, and
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J P Bergerat, and
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Cancer treatment reports,
J P Bergerat, and
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Gan to kagaku ryoho. Cancer & chemotherapy,
J P Bergerat, and
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Cancer treatment reports,
J P Bergerat, and
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B Drewinko
August 1977,
Cancer treatment reports,
