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The pharmacokinetics of non-protein-bound platinum species derived from cis-dichlorodiammineplatinum(II) (cis-platinum) was studied under a variety of dosing conditions. Following rapid infusions (15-minute) of cis-platinum at 100 mg/m2, the unbound drug declined in a biphasic mode with a mean terminal half-life of 48 minutes. The mean beta-phase half-life after a 6-hour infusion of the same dose of cis-platinum was 26 minutes. Urinary excretion of filterable platinum was substantially greater after a 6-hour infusion than after a 15-minute injection. Concomitant administration of mannitol appeared to result in higher peak plasma concentrations and decreased urinary excretion of unbound platinum species but did not alter the terminal half-life. Renal impairment was associated with extremely high plasma levels of filterable platinum but did not affect other pharmacokinetic parameters. Preliminary data on the distribution of cis-platinum to ascitic fluid are also presented.
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April 1982,
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Clinical chemistry,
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Gan to kagaku ryoho. Cancer & chemotherapy,
R J Belt, and
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L A Sternson, and
A J Repta
May 1979,
Journal of chromatography,
R J Belt, and
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T F Patton, and
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L A Sternson, and
A J Repta
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Cancer treatment reports,
R J Belt, and
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T F Patton, and
S J Bannister, and
L A Sternson, and
A J Repta
February 1985,
Antimicrobial agents and chemotherapy,
