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The sera of patients with acute and chronic schistosomasis were tested for the presence of circulating immune complexes with the 125I-Clq binding assay. Fourteen out of fifteen (93%) patients with acute schistosomiasis had elevated 125I-Clq binding activity, while only two out of eleven (18%) patients with chronic disease had C1q binding complexes. This difference was significant (P less than 0.001) and paralleled the degree of clinical didsease activity between the two groups of patients. IgG and IgM were readily detected in all of these circulating complexes but the specific parasite antigens initiating their formation could not be defined. The level of circulating immune complexes was inversely correlated with the absolute eosinophil counts for individuals in the acutely infected group, an observation compatible wiht the hypothesis that a functional role for the eosinophil is the destruction and elimination of immune complexes.
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
July 1977,
Immunology,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
May 1975,
British medical journal,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
May 1975,
British medical journal,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
January 1997,
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
January 1989,
Neoplasma,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
September 1989,
British journal of urology,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
January 1977,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
January 1983,
The American journal of tropical medicine and hygiene,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
October 1981,
British journal of haematology,
T J Lawley, and
E A Ottesen, and
R A Hiatt, and
L A Gazze
November 1983,
Bulletin de la Societe de pathologie exotique et de ses filiales,
