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The effect of prostaglandin E1 (PGE1) on plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was studied in the hypertensive subjects treated with or without 75 mg indomethacin or 60 mg propranolol for a week. Subsequent to the treatment with indomethacin for a week, PRA and PAC levels were decreased as compared to the control, without changes in the blood pressure and heart rate. During the infusion of PGE1, the blood pressure was decreased and the pulse rate was increased. PRA and PAC levels were also elevated. These changes of parameters were not different between the control and the indomethacin-treated subjects. PRA and PAC were suppressed after the treatment with propranolol. With the infusion of PGE1, the level of PRA was not significantly elevated, while, PAC was significantly increased by the infusion of 100 ng/Kg/min of PGE1. During the infusion of PGE1, the blood pressure was decreased while the pulse rate was increased in the subjects treated with propranolol. However, the elevation of the pulse rate was less remarkable than the control. These data indicate that PGE1 have important roles in the regulation of the release of renin and aldosterone. These findings also suggest that PGE1 may act to stimulate the secretion of aldosterone in man.
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
January 1993,
The Journal of international medical research,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
January 1980,
International journal of clinical pharmacology, therapy, and toxicology,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
April 1971,
The American journal of physiology,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
July 1976,
Clinical science and molecular medicine,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
May 2016,
Orvosi hetilap,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
January 1986,
Advances in experimental medicine and biology,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
October 1976,
Circulation research,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
January 1978,
Bollettino della Societa italiana di cardiologia,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
August 1975,
The Tohoku journal of experimental medicine,
M Yoshimura, and
H Takahashi, and
R Takashina, and
Y Kajita, and
T Miyazaki, and
T Hachiya, and
H Ijichi, and
Y Ochi
May 1982,
The Tohoku journal of experimental medicine,
