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The genetic control of antibody affinity has been studied in mice selectively bred on the basis of the affinity of antibody they produce to protein antigens injected in saline. Two lines of mice have been obtained, one producing predominantly high and the other predominantly low affinity antibody. Breeding experiments have been performed with these two lines after ten generations of selection and the level and affinity of antibody to protein measured in parents, F1 hybrids and backcross offspring. The results indicate that antibody affinity is a genetically controlled parameter of the immune response and that this control is exerted independently of that controlling antibody levels. Furthermore, high and low affinity line mice have been typed for major histocompatibility complex antigens and the results show that the two lines are not significantly different. This therefore suggests that genes controlling antibody affinity are not linked to the major histocompatibility locus.
M W Steward, and
M C Reinhardt, and
N A Staines
June 1976,
Immunology,
M W Steward, and
M C Reinhardt, and
N A Staines
January 1986,
European journal of immunology,
M W Steward, and
M C Reinhardt, and
N A Staines
October 1980,
Immunology,
M W Steward, and
M C Reinhardt, and
N A Staines
April 1990,
Immunology,
M W Steward, and
M C Reinhardt, and
N A Staines
February 1989,
Psychological reports,
M W Steward, and
M C Reinhardt, and
N A Staines
February 1995,
Pain,
M W Steward, and
M C Reinhardt, and
N A Staines
December 1994,
Behavioral neuroscience,
M W Steward, and
M C Reinhardt, and
N A Staines
September 2019,
Brain sciences,
M W Steward, and
M C Reinhardt, and
N A Staines
April 2023,
Genes, brain, and behavior,
M W Steward, and
M C Reinhardt, and
N A Staines
November 1998,
Neuroscience letters,
