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-Ketosidic linkage of the neuraminidase-resistent neuraminic acid in brain gangliosides. 1972

R T Huang, and E Klenk

UI MeSH Term Description Entries
D009438 Neuraminic Acids Nine-carbon deoxyamino SUGAR ACIDS that are substrates for NEURAMINIDASE. Their derivatives include SIALIC ACIDS. Acids, Neuraminic
D009439 Neuraminidase An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992) Sialidase,Exo-alpha-Sialidase,N-Acylneuraminate Glycohydrolases,Oligosaccharide Sialidase,Exo alpha Sialidase,Glycohydrolases, N-Acylneuraminate,N Acylneuraminate Glycohydrolases,Sialidase, Oligosaccharide
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002621 Chemistry A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D005732 Gangliosides A subclass of ACIDIC GLYCOSPHINGOLIPIDS. They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. Using the Svennerholm system of abbrevations, gangliosides are designated G for ganglioside, plus subscript M, D, or T for mono-, di-, or trisialo, respectively, the subscript letter being followed by a subscript arabic numeral to indicated sequence of migration in thin-layer chromatograms. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1997) Ganglioside,Sialoglycosphingolipids
D055598 Chemical Phenomena The composition, structure, conformation, and properties of atoms and molecules, and their reaction and interaction processes. Chemical Concepts,Chemical Processes,Physical Chemistry Concepts,Physical Chemistry Processes,Physicochemical Concepts,Physicochemical Phenomena,Physicochemical Processes,Chemical Phenomenon,Chemical Process,Physical Chemistry Phenomena,Physical Chemistry Process,Physicochemical Phenomenon,Physicochemical Process,Chemical Concept,Chemistry Process, Physical,Chemistry Processes, Physical,Concept, Chemical,Concept, Physical Chemistry,Concept, Physicochemical,Concepts, Chemical,Concepts, Physical Chemistry,Concepts, Physicochemical,Phenomena, Chemical,Phenomena, Physical Chemistry,Phenomena, Physicochemical,Phenomenon, Chemical,Phenomenon, Physicochemical,Physical Chemistry Concept,Physicochemical Concept,Process, Chemical,Process, Physical Chemistry,Process, Physicochemical,Processes, Chemical,Processes, Physical Chemistry,Processes, Physicochemical

Related Publications

R T Huang, and E Klenk
Glycolyl-neuraminic acid in ox brain gangliosides.
April 1965, Nature,
R T Huang, and E Klenk
[Structure of brain gangliosides and of neuraminic-acid-containing oligosaccharides in milk].
January 1973, Zentralblatt fur Veterinarmedizin. Reihe A,
R T Huang, and E Klenk
The linkage neuraminic acid in orosomucoid.
April 1959, Biochimica et biophysica acta,
R T Huang, and E Klenk
Studies on the structure of gangliosides. I. On the linkage of N-acetyl neuraminic acid in monosialoganglioside.
May 1963, Biochemical and biophysical research communications,
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On the specificity of neuraminidase. Synthesis of benzyl 5-acetamido-3,5-dideoxy-beta-L-arabino-heptulosidaric acid, an a-ketosidic dicarboxylic derivative of N-acetyl-D-neuraminic acid resistant to Vibrio cholerae neuraminidase.
April 1974, FEBS letters,
R T Huang, and E Klenk
[Neuraminic acid aldolase and neuraminidase in animal tissues].
January 1965, Biokhimiia (Moscow, Russia),
R T Huang, and E Klenk
Incorporation of [14C]N-acetyl neuraminic acid into brain glycoproteins and gangliosides in vivo.
January 1971, Journal of neurochemistry,
R T Huang, and E Klenk
Inhibition of neuraminidase with neuraminic acid C-glycosides.
May 2000, Bioorganic & medicinal chemistry letters,
R T Huang, and E Klenk
On the discovery and chemistry of neuraminic acid and gangliosides.
October 1970, Chemistry and physics of lipids,
R T Huang, and E Klenk
Neuraminic acid-specific modification and tritium labelling of gangliosides.
January 1976, Biochimica et biophysica acta,
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