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The antihypertensive effect on the selective beta-1-adrenoceptor blocking agent, atenolol, given in doses of 100 and 200 mg once daily, was evaluated in 37 patients with primary hypertension. The drug induced an efficient reduction of BP, and in the whole patient series there was no difference in BP on either dosage. Exercise tests, performed in 10 patients, showed the same degree of partial beta-blockade 24 hours after intake of 100 and 200 mg atenolol. PRA decreased during treatment with atenolol but there was no correlation between the stimulated pretreatment renin level and the antihypertensive effect of atenolol. Side-effects were few and 35 out of 37 patients continued on atenolol treatment. Central nervous side-effects were not seen.
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
March 1979,
Clinical pharmacology and therapeutics,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
November 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
February 1979,
British medical journal,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
January 1979,
British medical journal,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
February 1979,
British medical journal,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
February 1979,
British medical journal,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
March 1979,
British medical journal,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
October 1977,
British journal of clinical pharmacology,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
June 1988,
Clinical and investigative medicine. Medecine clinique et experimentale,
O R Nilsson, and
B E Karlberg, and
O Ohlsson, and
T Thulin, and
K Tolagen
September 1984,
Japanese circulation journal,
