Biomaterial Database

Dependence of functional vasodilatation in the cat submaxillary gland upon stimulation frequency. 1972

A C Darke, and L H Smaje

1. Submaxillary gland blood flow and salivation have been measured in anaesthetized cats and the chorda-lingual nerve has been stimulated at different frequencies.2. At low stimulation frequencies (1-5 Hz) there was a large transient increase in blood flow followed by a more modest maintained increase which lasted as long as stimulation continued. Stimulation at 10-20 Hz also produced a rapid initial increase in flow but at these frequencies the subsequent decline was not seen and a gradual further increase to a maintained level was observed.3. Atropine in small doses depressed both the transient and the maintained response to low frequency stimulation but at 10-20 Hz the maintained vasodilatation was unaffected by the drug.4. The transient increase in potassium concentration in saliva and venous blood draining the gland was not correlated with the vascular response.5. In conclusion, further details have been provided concerning the vascular response to chorda-lingual nerve stimulation and its sensitivity to atropine. Functional vasodilatation is not secondary to potassium release and is not due to a direct interaction between rate of saliva production and rate of blood flow although the vasodilatation does appear to be related in part to the acompanying salivation.

UI	MeSH Term	Description	Entries
D008036	Lingual Nerve	A sensory branch of the MANDIBULAR NERVE, which is part of the trigeminal (5th cranial) nerve. The lingual nerve carries general afferent fibers from the anterior two-thirds of the tongue, the floor of the mouth, and the mandibular gingivae.	Lingual Nerves,Nerve, Lingual,Nerves, Lingual
D008297	Male		Males
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D001808	Blood Vessels	Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).	Blood Vessel,Vessel, Blood,Vessels, Blood
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002814	Chorda Tympani Nerve	A branch of the facial (7th cranial) nerve which passes through the middle ear and continues through the petrotympanic fissure. The chorda tympani nerve carries taste sensation from the anterior two-thirds of the tongue and conveys parasympathetic efferents to the salivary glands.	Chorda Tympani Nerves,Nerve, Chorda Tympani,Nerves, Chorda Tympani,Tympani Nerve, Chorda,Tympani Nerves, Chorda
D004106	Dilatation	The act of dilating.	Dilation,Dilatations,Dilations
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia