Effect of chronic N,N-diethylnitrosamine on the excision of O6-ethylguanine from rat liver DNA.
1979
G P Margison, and
N J Curtin, and
K Snell, and
A W Craig
UI
MeSH Term
Description
Entries
D008099
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Livers
D008297
Male
Males
D009602
Nitrosamines
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
Nitrosamine
D004052
Diethylnitrosamine
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D004260
DNA Repair
The removal of DNA LESIONS and/or restoration of intact DNA strands without BASE PAIR MISMATCHES, intrastrand or interstrand crosslinks, or discontinuities in the DNA sugar-phosphate backbones.
DNA Damage Response
D006147
Guanine
D000225
Adenine
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Vitamin B 4,4, Vitamin B,B 4, Vitamin
D000478
Alkylation
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
Alkylations
D000818
Animals
Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.
Animal,Metazoa,Animalia
Related Publications
G P Margison, and
N J Curtin, and
K Snell, and
A W Craig