-transparent.png){kind=logo}
The activity of 5-aminolevulinate dehydratase (ALAD) in rabbit blood is significantly inhibited by tin. Intravenous administration of tin (0.48 or 4.8 mumol/kg body weight) causes a decrease in the activity of the enzyme by 60% or 94% respectively. The effects of tin and lead on ALAD differ: inhibition by tin is not affected by pre-incubation at 50-60 degrees C, whereas the inhibitory effect of lead is increased by the same pretreatment. The optimum pH for rabbit blood ALAD is 6.8 in control rabbits. This optimum shifts to pH 5.8-6.0 in the blood of tin-treated rabbits, with or without pre-incubation at 60 degrees C for 5 min, while a similar shift is prevented by the same pre-incubation after lead treatment. Recovery to normal activity is faster after tin than after lead treatment.
M Chiba, and
M Kikuchi
April 1980,
Clinical chemistry,
M Chiba, and
M Kikuchi
January 1981,
International archives of occupational and environmental health,
M Chiba, and
M Kikuchi
October 2018,
Toxicology letters,
M Chiba, and
M Kikuchi
March 2001,
Environmental research,
M Chiba, and
M Kikuchi
January 1982,
International archives of occupational and environmental health,
M Chiba, and
M Kikuchi
May 2001,
Current protocols in toxicology,
M Chiba, and
M Kikuchi
August 1989,
Plant physiology,
M Chiba, and
M Kikuchi
October 1992,
Toxicology,
M Chiba, and
M Kikuchi
January 1962,
Biochimica et biophysica acta,
M Chiba, and
M Kikuchi
July 1975,
Biochemical and biophysical research communications,
