-transparent.png){kind=logo}
Solutions of conventional stoma-free hemoglobin (SFH) and of pyridoxylated stoma-free hemoglobin (SFH-PLP) were compared in a dog model of reanimation from severe arterial blood loss. SFH and SFH-PLP restored central hemodynamics after infusion without yielding significant differences between the experimental groups. To cope with the developing hypovolemia, Ringer's lactate load amounted to about 120 ml/kg, edema formation was not encountered. Skeletal muscle oxygenation was studied by means of a multiwire platin electrode. The infusion of SFH-PLP was associated with a shift to the right of the cumulative PO2-distribution curve, indicating better tissue oxygenation. Oxygen was not unloaded from SFH in plasma unless the oxygen extraction from red cell hemoglobin exceeded 40%. Oxygen unloading was, however, improved when SFH-PLP with low oxygen affinity was used. Thus, SFH-PLP merits further consideration as a short-term oxygen-carrying blood substitute.
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
January 2003,
Journal of veterinary internal medicine,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
January 1976,
Ceskoslovenska fysiologie,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
January 2004,
Methods in enzymology,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
January 1984,
Advances in experimental medicine and biology,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
December 2004,
American journal of physiology. Heart and circulatory physiology,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
January 1977,
Advances in experimental medicine and biology,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
February 1980,
The American journal of physiology,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
April 1984,
Journal of developmental physiology,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
September 1989,
Akusherstvo i ginekologiia,
K Messmer, and
F Jesch, and
B Endrich, and
J Hobbhahn, and
W Peters, and
M Schoenberg
December 2003,
Critical care medicine,
