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The median effective doses (ED(50)) of 28 lots of killed Pasteurella pestis strain 195/P vaccine were determined in mice and guinea pigs. Mice were injected with vaccine alone, whereas guinea pigs received vaccine suspended in incomplete Freund's adjuvant. Potency ratios of vaccines were obtained by comparing the ED(50) of the test with that of a reference vaccine. Mean potency ratios of 1.82 +/- 0.50 in mice and 3.22 +/- 0.56 in guinea pigs were obtained, and the difference between these means was significant, P = <0.01. The number of organisms in the challenge dose did not significantly affect the ED(50) of a vaccine in guinea pigs. However, irrespective of vaccinating route, nearly 1,000 times as much vaccine was required in the absence of adjuvant as in its presence to produce comparable protective indexes in the guinea pig. The response of guinea pigs did not offer any improvement over mice in evaluating the efficacy of plague vaccines.
E von Metz, and
D M Eisler, and
G A Hottle
April 2011,
The American journal of pathology,
E von Metz, and
D M Eisler, and
G A Hottle
April 1968,
The Journal of infectious diseases,
E von Metz, and
D M Eisler, and
G A Hottle
March 1951,
Archives de l'Institut Pasteur d'Algerie. Institut Pasteur d'Algerie,
E von Metz, and
D M Eisler, and
G A Hottle
May 2004,
The Journal of rheumatology,
E von Metz, and
D M Eisler, and
G A Hottle
July 1985,
Journal of biological standardization,
E von Metz, and
D M Eisler, and
G A Hottle
December 1907,
The Indian medical gazette,
E von Metz, and
D M Eisler, and
G A Hottle
February 1966,
British journal of experimental pathology,
E von Metz, and
D M Eisler, and
G A Hottle
September 1999,
Vaccine,
E von Metz, and
D M Eisler, and
G A Hottle
October 1946,
Public health reports (Washington, D.C. : 1896),
E von Metz, and
D M Eisler, and
G A Hottle
December 1979,
American journal of veterinary research,
