Urinary pepsinogen isozymes: a highly polymorphic locus in man. 1979

R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally

A genetic analysis of human urinary pepsinogen isozymes is presented. Nine discrete phenotypes were identified in a population survey of 215 unrelated Caucasian individuals. The phenotypes were characterized by differences among the staining intensities of the activated group I pepsinogens, Pg 5, Pg 4, Pg 3, and Pg 2. The genetic studies demonstrated that the codominant expression of four alleles, PgA, PgB, PgC and PgD, at a single genetic locus determined the nine phenotypes identified. Linkage analysis excluded close linkage of the Pg locus with the chromosome 6 markers HLA, GLO1, and Bf.

UI MeSH Term Description Entries
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D008040 Genetic Linkage The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. Genetic Linkage Analysis,Linkage, Genetic,Analyses, Genetic Linkage,Analysis, Genetic Linkage,Genetic Linkage Analyses,Linkage Analyses, Genetic,Linkage Analysis, Genetic
D010435 Pepsinogens Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs. Pepsinogen B
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
November 1980, Proceedings of the National Academy of Sciences of the United States of America,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
July 1987, Jikken dobutsu. Experimental animals,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
February 1993, Animal genetics,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
June 1994, Animal genetics,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
December 1997, Animal genetics,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
January 2003, Forensic science international,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
April 1999, Animal genetics,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
January 1990, Journal of lipid research,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
September 1995, The Japanese journal of human genetics,
R T Taggart, and R C Karn, and A D Merritt, and P L Yu, and P M Conneally
October 1991, Annals of human genetics,
Copied contents to your clipboard!