Biomaterial Database

Amberlite hemoperfusion in the treatment of acute drug intoxication. 1979

J L Rosenbaum, and M S Kramer, and R M Raja

Hemoperfusion is more effective than hemodialysis in clearing drugs from the blood of patients with acute overdose. In addition, the clinical improvement in the depth of coma is dramatic during hemoperfusion. There is normalization of the respiratory and circulatory systems usually within one hour, and response to verbal command within a few hours of initiating treatment. Amberlite XAD-4 is an unchanged polystyrene resin with a particular adsorptive attraction for lipid-soluble drugs. It is a more effective adsorbent than some of the coated or uncoated carbons in clearing blood of most of the drugs commonly involved in life-threatening acute overdose.

UI	MeSH Term	Description	Entries
D007475	Ion Exchange Resins	High molecular weight, insoluble polymers which contain functional groups that are capable of undergoing exchange reactions (ION EXCHANGE) with either cations or anions.	Ion Exchange Resin,Exchange Resin, Ion,Exchange Resins, Ion,Resin, Ion Exchange,Resins, Ion Exchange
D007688	Kidneys, Artificial	Devices which can substitute for normally functioning KIDNEYS in removing components from the blood by DIALYSIS that are normally eliminated in the URINE.	Artificial Kidney,Kidney, Artificial,Artificial Kidneys,Blood Dialyser,Blood Dialyzers,Hemodialyser,Hemodialyzers,Renal Dialysis Machine,Blood Dialysers,Blood Dialyzer,Dialyser, Blood,Dialysers, Blood,Dialysis Machine, Renal,Dialysis Machines, Renal,Dialyzer, Blood,Dialyzers, Blood,Hemodialysers,Hemodialyzer,Machine, Renal Dialysis,Machines, Renal Dialysis,Renal Dialysis Machines
D011041	Poisoning	A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.	Poisonings
D011137	Polystyrenes	Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.	Polystyrol,Polystyrene,Polystyrols
D006464	Hemoperfusion	Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).	Hemosorption,Hemoperfusions,Hemosorptions
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia