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Substance P-like immunoreactivity was located in nerves in the lungs of guinea pig, rat, mouse and neonatal pigs. These nerves were regularly observed in association with both airways and blood vessels in all region of the lung. They appeared to be more numerous in the guinea pig than in the other mammals studied and differences in distribution were observed. The finding of substance P-like immunoreactive nerves in the lung suggests the presence of another regulatory system within the mammalian lung.
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