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It is recognized that serum alkaline phosphatase may reflect enzyme contributions from bone, liver, and intestine. We have investigated serum alkaline phosphatases in two siblings with hypophosphatasia. After administration of long-chain triglycerides, the major alkaline phosphatase component of their sera was shown to be of intestinal origin on the basis of inhibition by l-phenylalanine. Starch block electrophoresis suggested that there were other regions of l-phenylalanine-sensitive alkaline phosphatase in addition to the major slow-moving intestinal band. Medium-chain triglycerides which are absorbed by the portal route did not cause a similar augmentation of intestinal alkaline phosphatase activity. These studies indicate that serum levels of intestinal alkaline phosphatase are increased normally after long-chain fat feeding in hypophosphatasia and may be the major component of total serum alkaline phosphatase activity.
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
April 2016,
Calcified tissue international,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
June 1985,
The New England journal of medicine,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
February 1960,
A.M.A. journal of diseases of children,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
May 1962,
Journal of clinical pathology,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
February 2014,
Clinical calcium,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
July 1983,
The Journal of laboratory and clinical medicine,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
June 1968,
The New England journal of medicine,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
February 2023,
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
February 1998,
Clinical science (London, England : 1979),
J B Warshaw, and
J W Littlefield, and
W H Fishman, and
N R Inglis, and
L L Stolbach
June 1996,
The Journal of clinical endocrinology and metabolism,
