BIOMAT Database Logo BIOMAT Database Logo

Potential folic acid antagonists. 5. Synthesis and dihydrofolate reductase inhibitory activities of 2-amino-4,6-substituted-5-arylazopyrimidines. 1971

S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne

UI MeSH Term Description Entries
D011743 Pyrimidines A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
D005493 Folic Acid Antagonists Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) Antifolate,Antifolates,Dihydrofolate Reductase Inhibitor,Folic Acid Antagonist,Dihydrofolate Reductase Inhibitors,Folic Acid Metabolism Inhibitors,Acid Antagonist, Folic,Acid Antagonists, Folic,Antagonist, Folic Acid,Antagonists, Folic Acid,Inhibitor, Dihydrofolate Reductase,Inhibitors, Dihydrofolate Reductase,Reductase Inhibitor, Dihydrofolate,Reductase Inhibitors, Dihydrofolate
D001391 Azo Compounds Organic chemicals where aryl or alkyl groups are joined by two nitrogen atoms through a double bond (R-N Azo Dye,Azo Dyes,Compounds, Azo,Dye, Azo,Dyes, Azo

Related Publications

S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Potential folic acid antagonists. 4. Synthesis and dihydrofolate reductase inhibitory activities of 2,4,6-triamino-5-arylazopyrimidines.
June 1971, Journal of medicinal chemistry,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Potential folic acid antagonists. I. The antitumor and folic acid reductase inhibitory properties of 6-substituted 2,4-diamino-5-arylazopyrimidines.
November 1965, Journal of medicinal chemistry,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Potential folic acid antagonists. 6. Potential irreversible folate reductase inhibitors derived from 2,4-diamino-5-arylazopyrimidines.
December 1971, Journal of medicinal chemistry,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production.
January 2014, Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Potential antineoplastics. I. 2-Amino-4,6-dimethyl-5-arylazopyrimidines and 1-thiocarbamoyl-3,5-diphenyl-4-arylazopyrazoles.
November 1969, Journal of medicinal chemistry,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists.
February 2016, Bioorganic & medicinal chemistry letters,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Potential folic acid antagonists. 3. The antitumor and folate reductase inhibitory properties of some irreversibly acting 6-N-substituted 2,4,6-triamino-5-(4-carbethoxyphenylazo)pyrimidines.
May 1968, Journal of medicinal chemistry,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Potential antineoplastics. IV. 2-amino-4-methyl-6-phenyl-5-arylazopyrimidines.
July 1970, Journal of medicinal chemistry,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Synthesis and aldose reductase inhibitory activities of novel O-substituted hydroxyphenylacetic acid derivatives.
October 2006, Archiv der Pharmazie,
S S Chatterjee, and S Ludwig, and J F Moran, and D J Triggle, and A Wayne
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.
February 1997, Journal of medicinal chemistry,
Copied contents to your clipboard!