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Detailed regional deposition of inhaled particles in the human lung is calculated for individual airway generations. The calculations are based on Landahl's deposition model as applied to the morphometric lung model of Weibel. We consider primarily deposition patterns of iron oxide particles with diameters ranging between 1 and 10 micrometers, but we also calculate patterns of deposition for bis(2-ethylhexyl) sebacate particles with diameters as small as 0.2 micrometers. We obtain good agreement between predicted values and observed values for alveolar retention of inhaled iron oxide particles with 64 and 20% of total deposition predicted to occur in nonciliated airways for 2- and 5-micrometer particles, respectively. This is compared with 48 +/- 9 and 27 +/- 10% for the measured values. Calculated values for total lung deposition of small bis(2-ethylhexyl) sebacate particles agree well with experimental data. The calculations show a minimum in deposition occurring for particle diameters of 0.5 micrometers, which is in agreement with observations. A calculation of surface concentration of deposited 7.9-micrometer aerodynamic particles reveals a very large concentration occurring at airway generation four. This observation is considered in light of observations that bronchial carcinomas occur in this vicinity of the lung.
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
March 1997,
American journal of respiratory and critical care medicine,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
August 1994,
The European respiratory journal,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
October 2017,
Pharmaceutical research,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
September 1993,
Pulmonary pharmacology,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
February 1985,
Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
July 1979,
Journal of applied physiology: respiratory, environmental and exercise physiology,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
July 2012,
Archivos de bronconeumologia,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
February 1969,
Nature,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
June 1986,
The American review of respiratory disease,
T R Gerrity, and
P S Lee, and
F J Hass, and
A Marinelli, and
P Werner, and
R V Lourenço
June 1976,
Environmental health perspectives,
