The effects of schedule-induced polydipsia (SIP) on pituitary-adrenal activity, as indicated by plasma levels of corticosterone, were examined in a series of experiments. Male (Experiments 1 and 3) and female (Experiment 2) rats were reduced to 80% of their free-feeding weight and given daily sessions on an intermittent-feeding schedule (fixed time of 60 sec). Half of the subjects in each experiment had water available during experimental sessions and the other half did not. Animals with water available in the experimental chamber exhibited SIP in all three experiments. In Experiment 1, blood samples were collected following (a) food consumption in the home cage, (b) a session on FT 60 sec, and (c) a session with pellets available in a cup in the experimental chamber. In Experiment 2, blood samples were taken prior to and following an FT 60-sec session, and following a session with pellets available in a cup in the chamber. In Experiment 3, pre- and postsession samples were obtained as in Experiment 2 (Part A). Subsequently, the opportunity to drink during sessions was removed, and the effect on corticoids was examined (Part B). The results indicate that (a) schedule-induced drinking suppresses pituitary-adrenal activity, (b) corticoid suppression may become a conditioned response to drinking in the chamber, and (c) corticoids return to presession levels following removal of water from the chamber. In view of these findings, it is hypothesized that SIP may serve an arousal-reducing role in intermittent-feeding situations.